Vein Conditions

Lipodermatosclerosis

Causes & Treatments

Lipodermatosclerosis, is a persistent inflammatory condition characterised by the thickening and hardening of the skin on the lower legs due to subcutaneous fibrosis.
lipodermatosclerosis lower

Who is at Risk of Developing Lipodermatosclerosis?

This condition mainly affects middle-aged and older adults, with a higher prevalence among women. Factors such as limited mobility and obesity are commonly associated with its occurrence.

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What Causes Lipodermatosclerosis?

The underlying cause of lipodermatosclerosis is venous insufficiency, which arises from issues such as faulty venous valves, blockages in venous outflow, and calf muscle pump dysfunction. These problems result in increased venous pressure, leading to an accumulation of leukocytes within the veins.

These white blood cells then migrate into the surrounding tissue, becoming activated and releasing proinflammatory cells and cytokines. This process promotes a chronic inflammatory state, ultimately causing an increase in collagen production and the subsequent fibrosis of subcutaneous fat.

Symptoms of Lipodermatosclerosis

Acute Phase:

During the acute phase, lipodermatosclerosis can be mistaken for cellulitis, presenting symptoms such as hardened skin, redness, pain, itching, aching, and a sensation of swelling or heaviness in one or, more frequently, both lower legs.

In this stage, symptoms might be confined to a single area, but they are generally more extensive. The regions most often impacted are the front or inner sides of the legs.

Chronic Phase:

In the chronic stage of lipodermatosclerosis, patients often experience persistent hardening, redness, and discomfort. This condition can lead to subcutaneous fibrosis, significantly narrowing the lower part of the leg and giving it a distinctive ‘upside-down champagne bottle’ look.

Additional symptoms associated with chronic venous insufficiency might also be evident, such as skin hyperpigmentation due to haemosiderin deposits, atrophie blanche, varicose veins, venous eczema, and the presence of venous ulcers.

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Lipodermatosclerosis

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Complications of Lipodermatosclerosis

Lipodermatosclerosis, characterised by chronic inflammation and fibrosis, often hinders wound healing. This condition frequently coincides with venous ulcers, which can be challenging to manage effectively.

How is Lipodermatosclerosis Diagnosed?

Lipodermatosclerosis is typically identified through clinical evaluation, with Doppler studies often used to confirm underlying venous insufficiency. Your vein clinic team can diagnose lipodermatosclerosis during your consultation.

Whilst a biopsy can provide additional insight, it must be approached cautiously due to the high risk of poor wound healing.

Lipodermatosclerosis Treatments

General Measures:

Encouraging physical activities such as walking is essential to enhance the effectiveness of the calf muscle pump. Additionally, weight reduction can be beneficial, particularly when obesity is a contributing factor.

Compression Therapy and Leg Elevation:

Mechanical compression therapy, which involves the use of compression stockings or socks, is a cornerstone of treatment. This approach aids venous return and helps manage symptoms, although it may not be well-tolerated by everyone. Elevating the legs can also assist in reducing oedema and alleviating pain.

Surgical Treatments:

Addressing underlying venous insufficiency can improve symptoms and reduce the risk of ulcer recurrence. Depending on the severity of the condition, available leg vein therapies include Endovenous Laser Ablation, as well as sclerotherapy and vein surgery.

hardened lipodermatosclerosis

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